一项随机前瞻性研究，比较头孢唑肟与头孢拉定在择期胆囊切除术中作为单剂量预防用药的效果。
A randomized prospective study to compare ceftizoxime with cephradine as single dose prophylaxis in elective cholecystectomy.
作者信息
Skipper D, Corder A P, Karran S J
机构信息
University Surgical Unit, Southampton General Hospital.
出版信息
J Hosp Infect. 1991 Apr;17(4):303-6. doi: 10.1016/0195-6701(91)90275-d.
This study compares the efficacy of ceftizoxime with that of cephradine as single agent prophylaxis in elective cholecystectomy. The incidence of purulent wound infection was low in both groups (ceftizoxime 1/99; cephradine 2/92). No adverse reactions to the trial antibiotics occurred in either group. Ceftizoxime is a safe, effective, convenient and well-tolerated antibiotic for use as single agent prophylaxis in elective cholecystectomy. However, because it has no demonstrable advantage over cephradine and is three times as expensive, its routine use is not justified.
本研究比较了头孢唑肟与头孢拉定作为择期胆囊切除术单药预防用药的疗效。两组的脓性伤口感染发生率均较低（头孢唑肟组1/99；头孢拉定组2/92）。两组均未出现对试验抗生素的不良反应。头孢唑肟是一种安全、有效、方便且耐受性良好的抗生素，可作为择期胆囊切除术的单药预防用药。然而，由于它与头孢拉定相比没有明显优势，且价格是头孢拉定的三倍，因此其常规使用不合理。
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