Manolis Antonis S, Patsouras Nikolaos, Ilias Ioannis, Constantakopoulos John, Pyriohou Anastasia, Lymperopoulos Anastasios, Spathas Dionysios H, Flordellis Christodoulos S
First Department of Cardiology, Evagelismos General Hospital of Athens, Athens, Greece.
Clin Chem Lab Med. 2006;44(7):807-12. doi: 10.1515/CCLM.2006.155.
A genetic association/prospective follow-up study was conducted to investigate whether genetic variation of the alpha(2B)-adrenergic receptor gene was associated with the risk of restenosis in 96 Greek coronary artery disease patients undergoing coronary angioplasty and stent implantation.
For comparison of genotype frequency, a control group of 83 asymptomatic individuals was also studied. The end-point of the current study was the incidence of restenosis at 7 months of clinical follow-up.
The majority of patients (70/96) had the insertion/insertion genotype, fewer patients (23/96) had the insertion/deletion genotype and only 3/96 had the deletion/deletion genotype; overall the frequency distribution was not different from that of the control subjects. Restenosis occurred in 15 of the 96 patients.
In the population studied, alpha(2B)-adrenoreceptor polymorphisms were not found to predispose patients to an increased incidence of restenosis. Nevertheless, these findings should be considered as preliminary, taking into account the small number of patients that were studied and the rarity of the deletion/deletion genotype.
开展了一项基因关联/前瞻性随访研究，以调查α（2B）-肾上腺素能受体基因的遗传变异是否与96例接受冠状动脉成形术和支架植入的希腊冠心病患者的再狭窄风险相关。
为比较基因型频率，还对83名无症状个体组成的对照组进行了研究。本研究的终点是临床随访7个月时再狭窄的发生率。
大多数患者（70/96）具有插入/插入基因型，较少患者（23/96）具有插入/缺失基因型，只有3/96具有缺失/缺失基因型；总体而言，频率分布与对照组无异。96例患者中有15例发生再狭窄。
在所研究的人群中，未发现α（2B）-肾上腺素能受体多态性使患者再狭窄发生率增加。然而，鉴于所研究的患者数量较少以及缺失/缺失基因型的罕见性，这些发现应被视为初步结果。
