Zhang Li-ping, Wang Shi-zhen, Zhao Xue-xin, Lian Bo, Wang Xiao-feng, Lin Ren-yong, Lu Da-ru, Jin Li
Xinjiang Medical University Biochemistry Department, Urumchi 830054, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2006 May;34(5):403-6.
To investigate the association between G894T polymorphism and essential hypertension (EH) in Uygur population in Xinjiang province.
In this case-control study, G894T genotypes in 375 hypertension patients (EH group) and 414 normotensive control subjects (NT group) from the rural area of Tuluafan of Xinjiang was investigated by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
(1) Significant differences were found in GG, GT and TT frequencies of G894T genotypes between the EH and NT groups (56.5%, 28.3%, 15.2% in EH group and 65.9%, 22.5%, 11.6% in NT group, OR = 2.97, 95% CI 1.393 - 6.358). T allele frequencies were significantly higher in EH group (29.33%) than that in NT group (22.83%, P < 0.05). (2) SBP, DBP in patients with T allele of eNOS gene [(171.36 +/- 22.30) mm Hg and (103.63 +/- 13.22) mm Hg] were significantly higher than that of GG genotype [(158.07 +/- 20.850) mm Hg and (89.90 +/- 10.39) mm Hg] (P < 0.01).
eNOS gene exon7 G894T polymorphism might relate to essential hypertension in Uygur population in Xinjiang province.
探讨新疆维吾尔族人群中G894T基因多态性与原发性高血压（EH）的关系。
在这项病例对照研究中，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，对新疆吐鲁番农村地区的375例高血压患者（EH组）和414例血压正常对照者（NT组）的G894T基因型进行了检测。
（1）EH组和NT组G894T基因型的GG、GT和TT频率存在显著差异（EH组分别为56.5%、28.3%、15.2%，NT组分别为65.9%、22.5%、11.6%，OR = 2.97，95%CI 1.393 - 6.358）。EH组的T等位基因频率（29.33%）显著高于NT组（22.83%，P < 0.05）。（2）携带eNOS基因T等位基因的患者收缩压（SBP）、舒张压（DBP）[（171.36 +/- 22.30）mmHg和（103.63 +/- 13.22）mmHg]显著高于GG基因型患者[（158.07 +/- 20.850）mmHg和（89.90 +/- 10.39）mmHg]（P < 0.01）。
eNOS基因外显子7 G894T多态性可能与新疆维吾尔族人群的原发性高血压有关。
