Yang Bing, Cao Ke-jiang, Shan Qi-jun, Xia Yun, Tu Jing, Chen Ming-long, Zou Jian-gang, Xu Dong-jie, Li Ku-lin, Chen Chun
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2006 May;34(5):429-32.
To study the characterization of time distribution of ventricular arrhythmias in patients with Brugada syndrome (BrS) using Holter monitoring and ICD follow-up.
Patients with BrS [all male, mean age (41.07 +/- 11.49) years], were divided into ventricular fibrillation (VF) group (n = 7) and no ventricular fibrillation (N-VF) group (n = 7). Premature ventricular capture (PVC) and VF episodes were detected by Holter monitoring and ICD recording.
The 24 hours total number of PVCs ranged from 0 to 74 (mean 9.61 +/- 17.23) in most of the patients and were similar between VF group and N-VF group. The percentage of PVC episodes in VF group was significantly higher than that in N-VF group from nocturnal time to early morning (22:00 to 7:00, 98.67% vs. 44.14%, P < 0.01). There were total 75 VF episodes during (23.18 +/- 17.96) months' follow-up in 5 patients with BrS, 93.3% of which occurred from nocturnal time to early morning (22:00 to 7:00).
The episodes of PVC were enriched from nocturnal time to early morning in BrS patients, this time distribution could be a new noninvasive risk stratification factor for BrS. The episodes of VF in BrS patients were also enriched from nocturnal time to early morning and this time characteristic of episodes of VF could be used to guide drug therapy.
采用动态心电图监测和植入式心律转复除颤器（ICD）随访，研究 Brugada 综合征（BrS）患者室性心律失常的时间分布特征。
BrS 患者[均为男性，平均年龄（41.07±11.49）岁]，分为心室颤动（VF）组（n = 7）和无心室颤动（N-VF）组（n = 7）。通过动态心电图监测和 ICD 记录检测室性早搏（PVC）和 VF 发作情况。
大多数患者 24 小时 PVC 总数在 0 至 74 次之间（平均 9.61±17.23），VF 组和 N-VF 组相似。VF 组从夜间至清晨（22:00 至 7:00）PVC 发作百分比显著高于 N-VF 组（98.67%对 44.14%，P < 0.01）。5 例 BrS 患者在（23.18±17.96）个月随访期间共发生 75 次 VF 发作，其中 93.3%发生在夜间至清晨（22:00 至 7:00）。
BrS 患者 PVC 发作在夜间至清晨时段更为集中，这一时间分布可能成为 BrS 新的无创危险分层因素。BrS 患者 VF 发作同样在夜间至清晨时段更为集中，这种 VF 发作的时间特征可用于指导药物治疗。
