转录暂停被当场捕获。

Transcriptional pausing caught in the act.

作者信息

von Hippel Peter H

机构信息

Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA.

出版信息

Cell. 2006 Jun 16;125(6):1027-8. doi: 10.1016/j.cell.2006.06.006.

DOI:10.1016/j.cell.2006.06.006

PMID:16777591

Abstract

Single-molecule techniques now permit the tracking of a transcription complex along a DNA template in real time and to 1 bp resolution. As reported in this issue of Cell, Herbert et al. (2006) exploit this approach to study a central component of transcription regulation, the sequence-dependent pausing of RNA polymerase during transcript elongation.

摘要

单分子技术现在能够实时追踪转录复合物沿着DNA模板移动的情况，分辨率可达1个碱基对。正如本期《细胞》杂志所报道的，赫伯特等人（2006年）利用这种方法来研究转录调控的一个核心成分，即RNA聚合酶在转录延伸过程中依赖序列的暂停。