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低剂量辐射可克服糖尿病诱导的大鼠海马神经元细胞增殖抑制。

Low dose radiation overcomes diabetes-induced suppression of hippocampal neuronal cell proliferation in rats.

作者信息

Kang Jin Oh, Kim Sang Ki, Hong Seong Eon, Lee Taeck Hyun, Kim Chang Ju

机构信息

Department of Radiation Oncology, School of Medicine, Kyung Hee University, Seoul, Korea.

出版信息

J Korean Med Sci. 2006 Jun;21(3):500-5. doi: 10.3346/jkms.2006.21.3.500.

DOI:10.3346/jkms.2006.21.3.500
PMID:16778397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2729959/
Abstract

We investigated the effect of low dose radiation on diabetes induced suppression of neurogenesis in the hippocampal dentate gyrus of rat. After 0.01 Gy, 0.1 Gy, 1 Gy and 10 Gy radiation was delivered, the dentate gyrus of hippocampus of streptozotocin (STZ)-induced diabetic rats were evaluated using immunohistochemistry for 5-bromo-2-deoxyuridine (BrdU), caspase-3, and terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) staining. The number of BrdU positive cells in the non-diabetic rats, diabetic rats without radiation, diabetic rats with 0.01 Gy radiation, diabetic rats with 0.1 Gy radiation, diabetic rats with 1 Gy radiation and diabetic rats with 10 Gy radiation were 55.4+/-8.5/mm2, 33.3+/-6.4/mm2, 67.7+/-10.5/mm2, 66.6+/-10.0/mm2, 23.5+/-6.3/mm2 and 14.3+/-7.2/mm2, respectively. The number of caspase-3 positive cells was 132.6+/-37.4/mm2, 378.6+/-99.1/mm2, 15.0+/-2.8/mm2, 57.1+/-16.9/mm2, 191.8+/-44.8/mm2 and 450.4+/-58.3/mm2, respectively. The number of TUNEL-positive cells was 24.5+/-2.0/mm2, 21.7+/-4.0/mm2, 20.4+/-2.0/mm2, 18.96+/-2.1/mm2, 58.3+/-7.9/mm2, and 106.0+/-9.8/mm2, respectively. These results suggest low doses of radiation paradoxically improved diabetes induced neuronal cell suppression in the hippocampal dentate gyrus of rat.

摘要

我们研究了低剂量辐射对链脲佐菌素（STZ）诱导的糖尿病大鼠海马齿状回神经发生抑制的影响。给予0.01 Gy、0.1 Gy、1 Gy和10 Gy辐射后，采用免疫组织化学法对5-溴-2-脱氧尿苷（BrdU）、半胱天冬酶-3和末端脱氧核苷酸转移酶介导的缺口末端标记（TUNEL）染色，评估STZ诱导的糖尿病大鼠海马齿状回情况。非糖尿病大鼠、未接受辐射的糖尿病大鼠、接受0.01 Gy辐射的糖尿病大鼠、接受0.1 Gy辐射的糖尿病大鼠、接受1 Gy辐射的糖尿病大鼠和接受10 Gy辐射的糖尿病大鼠中，BrdU阳性细胞数分别为55.4±8.5/mm²、33.3±6.4/mm²、67.7±10.5/mm²、66.6±10.0/mm²、23.5±6.3/mm²和14.3±7.2/mm²。半胱天冬酶-3阳性细胞数分别为132.6±37.4/mm²、378.6±99.1/mm²、15.0±2.8/mm²、57.1±16.9/mm²、191.8±44.8/mm²和450.4±58.3/mm²。TUNEL阳性细胞数分别为24.5±2.0/mm²、21.7±4.0/mm²、20.4±2.0/mm²、18.96±2.1/mm²、58.3±7.9/mm²和106.0±9.8/mm²。这些结果表明，低剂量辐射反而改善了糖尿病诱导的大鼠海马齿状回神经元细胞抑制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de02/2729959/8b2bbe5b2b7e/jkms-21-500-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de02/2729959/cfc959a0821d/jkms-21-500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de02/2729959/c2bc707ee09d/jkms-21-500-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de02/2729959/15a53b226ce0/jkms-21-500-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de02/2729959/8b2bbe5b2b7e/jkms-21-500-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de02/2729959/cfc959a0821d/jkms-21-500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de02/2729959/c2bc707ee09d/jkms-21-500-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de02/2729959/15a53b226ce0/jkms-21-500-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de02/2729959/8b2bbe5b2b7e/jkms-21-500-g004.jpg

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本文引用的文献

1
Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes.
Brain Res. 2005 Mar 15;1038(1):22-31. doi: 10.1016/j.brainres.2004.12.032.
2
Evidence for beneficial low level radiation effects and radiation hormesis.低剂量辐射有益效应及辐射兴奋效应的证据。
Br J Radiol. 2005 Jan;78(925):3-7. doi: 10.1259/bjr/63353075.
3
The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function.糖耐量受损、2型糖尿病与认知功能之间的关系。
Anti-apoptotic and antioxidant effects of low dose gamma irradiation against diabetes-induced brain injury in rats.
低剂量γ射线辐射对糖尿病诱导的大鼠脑损伤的抗凋亡和抗氧化作用。
Radiat Environ Biophys. 2016 Nov;55(4):451-460. doi: 10.1007/s00411-016-0665-2. Epub 2016 Aug 26.
4
The Effect of Diabetes Mellitus on Apoptosis in Hippocampus: Cellular and Molecular Aspects.糖尿病对海马体细胞凋亡的影响：细胞和分子层面
Int J Prev Med. 2016 Mar 10;7:57. doi: 10.4103/2008-7802.178531. eCollection 2016.
5
Existence of a potential neurogenic system in the adult human brain.成人大脑中潜在神经发生系统的存在。
J Transl Med. 2014 Mar 22;12:75. doi: 10.1186/1479-5876-12-75.
6
Effects of diabetes on hippocampal neurogenesis: links to cognition and depression.糖尿病对海马神经发生的影响：与认知和抑郁的关系。
Neurosci Biobehav Rev. 2013 Sep;37(8):1346-62. doi: 10.1016/j.neubiorev.2013.03.010. Epub 2013 May 13.
7
Low-dose radiation activates Akt and Nrf2 in the kidney of diabetic mice: a potential mechanism to prevent diabetic nephropathy.低剂量辐射激活糖尿病小鼠肾脏中的 Akt 和 Nrf2：预防糖尿病肾病的潜在机制。
Oxid Med Cell Longev. 2012;2012:291087. doi: 10.1155/2012/291087. Epub 2012 Nov 27.
8
Adaptive responses induced by low dose radiation in dentate gyrus of rats.低剂量辐射诱导大鼠齿状回的适应性反应。
J Korean Med Sci. 2006 Dec;21(6):1103-7. doi: 10.3346/jkms.2006.21.6.1103.
J Clin Exp Neuropsychol. 2004 Nov;26(8):1044-80. doi: 10.1080/13803390490514875.
4
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function.糖尿病与阿尔茨海默病风险及认知功能衰退
Arch Neurol. 2004 May;61(5):661-6. doi: 10.1001/archneur.61.5.661.
5
Extreme sensitivity of adult neurogenesis to low doses of X-irradiation.成年神经发生对低剂量X射线辐射极度敏感。
Cancer Res. 2003 Jul 15;63(14):4021-7.
6
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Int J Sports Med. 2003 Feb;24(2):114-7. doi: 10.1055/s-2003-38202.
7
Radiation injury and neurogenesis.辐射损伤与神经发生
Curr Opin Neurol. 2003 Apr;16(2):129-34. doi: 10.1097/01.wco.0000063772.81810.b7.
8
Hypothermia inhibits cell proliferation and nitric oxide synthase expression in rats.体温过低会抑制大鼠的细胞增殖和一氧化氮合酶表达。
Neurosci Lett. 2002 Aug 23;329(1):53-6. doi: 10.1016/s0304-3940(02)00591-8.
9
Hippocampal neuronal apoptosis in type 1 diabetes.1型糖尿病中的海马神经元凋亡
Brain Res. 2002 Aug 16;946(2):221-31. doi: 10.1016/s0006-8993(02)02887-1.
10
Functional neurogenesis in the adult hippocampus.成年海马体中的功能性神经发生
Nature. 2002 Feb 28;415(6875):1030-4. doi: 10.1038/4151030a.