Bornkessel Anja, Weyers Wolfgang, Elsner Peter, Ziemer Mirjana
Department of Pathology, Friedrich-Schiller-University of Jena, Germany.
Am J Dermatopathol. 2006 Jun;28(3):220-2. doi: 10.1097/00000372-200606000-00009.
Epidermotropic metastases from internal malignancies are exceedingly rare. We report a striking example of epidermotropic metastatic carcinoma of the lower female genital tract to the skin of the abdomen and groin. Atypical cells were scattered throughout the epidermis, mimicking Bowen's disease. Focally, islands of atypical squamous cells were also found in the adjacent dermis. Histopathologically, the lesion resembled a primary invasive squamous cell carcinoma. However, the clinical history of a metastatic carcinoma of the genitalia and the clinical presentation with multiple lesions militated against a primary squamous cell carcinoma and favored interpretation of the lesions as epidermotropic metastases.
来自体内恶性肿瘤的亲表皮转移极为罕见。我们报告了一例女性下生殖道亲表皮转移性癌转移至腹部和腹股沟皮肤的显著病例。非典型细胞散在于整个表皮，酷似鲍恩病。局部区域，在相邻真皮层也发现了非典型鳞状细胞岛。组织病理学上，该病变类似于原发性浸润性鳞状细胞癌。然而，生殖器转移性癌的临床病史以及多发病变的临床表现不支持原发性鳞状细胞癌的诊断，而倾向于将这些病变解释为亲表皮转移。
