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炎性腹主动脉瘤与冠状动脉疾病。病例报告及文献综述。

The inflammatory abdominal aortic aneurysm and coronary artery disease. Case report and review.

作者信息

Monte I, Capodanno D, Licciardi S, Ferraro C, Giannone M T, Grasso S, Nicolosi E

机构信息

Department of Internal Medicine and Specialistic Medicine, University of Catania, Catania, Italy.

出版信息

Minerva Cardioangiol. 2006 Apr;54(2):265-71.

Abstract

Inflammatory abdominal aortic aneurysm (IAAA) is defined as an unusually thickened aneurysmatic wall, encircled by a wide dense perianeurysmal and/or retroperitoneal fibrosis with adjacent tissues adhesion, and is now considered as an extreme shape of the common phlogistic process involved in atherosclerotic plaque formation. Latest studies demonstrated that inflammation plays an important role in coronary disease and in other atherosclerosis manifestations. We introduce the clinical case of a patient with IAAA who developed an acute myocardial infarction 6 months after the surgical procedure on the aorta. Through a literature review about IAAA we stress the clinical usefulness of the inflammatory markers as independent predictors in management of patients with coronary disease and we present the hypothesis, related to the introduced case, of an advanced coronary disease, aggravated or clinically revealed after the cytokine storm related to important localized inflammatory engagements or great vascular surgery treatments.

摘要

炎性腹主动脉瘤(IAAA)的定义为动脉瘤壁异常增厚,周围环绕着广泛致密的动脉瘤周围和/或腹膜后纤维化以及相邻组织粘连,目前被认为是参与动脉粥样硬化斑块形成的常见炎症过程的一种极端形式。最新研究表明,炎症在冠状动脉疾病和其他动脉粥样硬化表现中起重要作用。我们介绍了一名IAAA患者的临床病例,该患者在主动脉手术后6个月发生了急性心肌梗死。通过对IAAA的文献综述,我们强调炎症标志物作为冠心病患者管理中独立预测指标的临床实用性,并针对所介绍的病例提出了一种假说,即与重要的局部炎症反应或大型血管手术治疗相关的细胞因子风暴后,已存在的冠状动脉疾病会加重或在临床上显现出来。

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