Rubini P, Bonati L, Parolari A, Spirito R
Istituto di Clinica Chirurgica Generale e dei Trapianti d Organo, Università degli Studi, Parma, Italy.
Minerva Chir. 2001 Jun;56(3):287-98.
The authors present a review of the literature on inflammatory abdominal aortic aneurysms. These aneurysms represent from 3 to 10% of all abdominal aortic aneurysms. Progress has occurred in the technical approach to these aneurysms, and operative morbidity and mortality have been remarkably reduced. However, the pathogenesis remains poorly understood. Early reports have considered the inflammatory aneurysm as a distinct clinical and pathological entity, whereas recent evidences suggest a common etiopathogenetic mechanism for both atherosclerotic and inflammatory aneurysms. Finally, genetic and environmental factors, such as tobacco use, may predispose certain persons to the development of non-inflammatory aneurysms and others to a wide spectrum of inflammatory reactions until inflammatory aneurysms development. The most common clinical features of these aneurysms are represented by symptoms, such as abdominal or back pain, obstructive uropathy and by an elevated erythrocyte sedimentation rate. Computed tomography (CT) allows a specific diagnosis by the typical image of soft tissue surrounding the aortic wall enhancing with contrast administration. Ultrasonography is less sensitive whereas nuclear magnetic resonance (RNM) is a promising technique. Excretory urography may suggest the diagnosis by demonstration of ureter entrapment. Surgical therapy, by a technique of limited dissection represents the definitive treatment. Evolution of fibrosis after surgery is still debated because some studies have reported complete regression of inflammation and other partial regression or persistence of fibrotic process. At present, endovascular treatment of these aneurysms is occasionally reported, although preliminary results appear satisfactory.
作者对炎性腹主动脉瘤的文献进行了综述。这些动脉瘤占所有腹主动脉瘤的3%至10%。在这些动脉瘤的技术处理方面已取得进展,手术发病率和死亡率显著降低。然而,其发病机制仍知之甚少。早期报告认为炎性动脉瘤是一种独特的临床和病理实体,而最近的证据表明动脉粥样硬化性和炎性动脉瘤存在共同的病因发病机制。最后,遗传和环境因素,如吸烟,可能使某些人易患非炎性动脉瘤,而另一些人易发生广泛的炎症反应直至炎性动脉瘤形成。这些动脉瘤最常见的临床特征表现为腹痛、背痛、梗阻性尿路病等症状以及红细胞沉降率升高。计算机断层扫描(CT)通过主动脉壁周围软组织在注射造影剂后增强的典型图像可做出特异性诊断。超声检查敏感性较低,而核磁共振(RNM)是一种有前景的技术。排泄性尿路造影可通过显示输尿管受压提示诊断。通过有限分离技术进行手术治疗是确定性治疗方法。术后纤维化的演变仍存在争议,因为一些研究报告炎症完全消退,而另一些研究则报告纤维化过程部分消退或持续存在。目前,尽管初步结果似乎令人满意,但偶尔也会报告对这些动脉瘤进行血管内治疗。