Suppr超能文献

非遗传性抗生素耐药性

Non-inherited antibiotic resistance.

作者信息

Levin Bruce R, Rozen Daniel E

机构信息

Department of Biology, Emory University, Atlanta, Georgia 30307, USA.

出版信息

Nat Rev Microbiol. 2006 Jul;4(7):556-62. doi: 10.1038/nrmicro1445.

Abstract

In addition to their impressive, well-publicized and well-researched propensity to evolve and acquire genetically determined mechanisms for resistance to antibiotics, bacteria that are inherently susceptible to these drugs can also be phenotypically refractory to their action. This phenomenon of 'non-inherited resistance' to antibiotics has been known since the beginning of the antibiotic era but, relative to inherited resistance, it has been given little attention. Here, we review the in vitro and in vivo evidence for the different forms of non-inherited resistance and the mechanisms responsible. With the aid of a simple mathematical model and computer simulations, we show how non-inherited resistance could extend the duration of antibiotic treatment, cause treatment failure and promote the generation and ascent of inherited resistance in treated patients.

摘要

除了它们那种令人印象深刻、广为人知且经过充分研究的进化倾向以及获得对抗生素的遗传决定抗性机制外,原本对这些药物敏感的细菌在表型上也可能对其作用产生耐药性。抗生素时代伊始就已知道这种“非遗传性耐药”现象,但相对于遗传性耐药,它一直很少受到关注。在这里,我们综述了非遗传性耐药不同形式的体外和体内证据以及相关机制。借助一个简单的数学模型和计算机模拟,我们展示了非遗传性耐药如何能够延长抗生素治疗的持续时间、导致治疗失败并促进治疗患者中遗传性耐药的产生和上升。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验