2,2'-联咪唑硝基衍生物的合成及其抗寄生虫活性
Snythesis and antiprotozoal activity of nitro derivatives of 2, 2'-biimidazole.
作者信息
Melloni P, Metelli R, Bassini D F, Confalonieri C, Logemann W, de Carneri I, Trane F
出版信息
Arzneimittelforschung. 1975 Jan;25(1):9-14.
PMID:167793
Abstract
We synthesized a series of 2,2'-biimidazoles with different substituents and screened them against Entamoeba histolytica, Trichomonas vaginalis and Giardia muris. A 5-nitro group is necessary for the inclusion of activity and an amino group exercises favourable effect on in vivi activity.
摘要
我们合成了一系列带有不同取代基的2,2'-联咪唑，并针对溶组织内阿米巴、阴道毛滴虫和鼠贾第虫对它们进行了筛选。5-硝基对于活性的具备是必要的，而氨基对体内活性有有利影响。
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