Sheiner Eyal, Ohel Iris, Levy Amalia, Katz Miriam
Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
J Reprod Med. 2006 May;51(5):394-8.
To investigate obstetric risk factors and pregnancy outcome in women with pruritus gravidarum who delivered during a 15-year period.
A population-based study comparing all pregnancies in women with and without pruritus gravidarum delivered between 1988 and 2002 was conducted. A multivariable logistic regression model was constructed in order to find independent risk factors associated with pruritus gravidarum.
During the study period there were 159,197 deliveries, of which 376 (0.2%) occurred in patients with pruritus gravidarum. Using a multivariable analysis, the following conditions were found to be significantly associated with pruritus gravidarum: twin pregnancies, fertility treatments, diabetes mellitus and nulliparity. No significant differences were noted between the groups regarding perinatal outcomes, such as birth weight, low Apgar scores or perinatal mortality. Pruritus gravidarum was associated with higher rates of labor induction, and accordingly those fetuses were more likely to be delivered by cesarean delivery.
Pruritus gravidarum, associated with multiple gestations, fertility treatments, diabetes mellitus and nulliparity, is not associated with adverse perinatal outcomes. However, there are higher rates of labor induction and cesarean delivery.
调查妊娠瘙痒症女性在15年期间分娩的产科危险因素及妊娠结局。
进行一项基于人群的研究，比较1988年至2002年间有和没有妊娠瘙痒症的女性的所有妊娠情况。构建多变量逻辑回归模型以找出与妊娠瘙痒症相关的独立危险因素。
在研究期间，共有159,197例分娩，其中376例（0.2%）发生在妊娠瘙痒症患者中。通过多变量分析发现，以下情况与妊娠瘙痒症显著相关：双胎妊娠、生育治疗、糖尿病和未生育。两组在围产期结局方面，如出生体重、低阿氏评分或围产期死亡率，未发现显著差异。妊娠瘙痒症与引产率较高相关，因此这些胎儿更有可能通过剖宫产分娩。
妊娠瘙痒症与多胎妊娠、生育治疗、糖尿病和未生育有关，但与不良围产期结局无关。然而，引产率和剖宫产率较高。
