Owecki Maciej, Sowiński Jerzy
Akademia Medyczna w Poznaniu, Katedra i Klinika Endokrynologii, Przemiany Materii i Chorób Wewnetrznych.
Pol Merkur Lekarski. 2006 Mar;20(117):355-7.
The paper reviews the structure and role of adiponectin in the regulation of metabolic balance. Adiponectin is the most abundant adipocytokine that is produced exclusively in the fat tissue. Its high concentration protects from diabetes mellitus, atherosclerosis and insulin resistance, its low concentration increases the risk of these disorders. The adiponectin gene is one of the many candidate genes in type 2 diabetes. Adiponectin binds to two types of receptors: 1 and 2, encoded by two genes: AdipoR1, and AdipoR2, respectively. The receptors are found in all tissues, with type 1 predominant in the muscles, and type 2 in the liver. Most importantly, the role of adiponectin in the body and the results of animal model experiments suggest the possible future use of adiponectin in the treatment of diabetes, atherosclerosis and obesity.
本文综述了脂联素在调节代谢平衡中的结构和作用。脂联素是脂肪组织中特有的最丰富的脂肪细胞因子。其高浓度可预防糖尿病、动脉粥样硬化和胰岛素抵抗，低浓度则会增加这些疾病的风险。脂联素基因是2型糖尿病众多候选基因之一。脂联素与两种类型的受体结合：分别由两个基因AdipoR1和AdipoR2编码的受体1和受体2。这些受体存在于所有组织中，其中受体1在肌肉中占主导，受体2在肝脏中占主导。最重要的是，脂联素在体内的作用以及动物模型实验结果表明，脂联素未来可能用于治疗糖尿病、动脉粥样硬化和肥胖症。
