Allan L D, Cook A, Sullivan I, Sharland G K
Department of Perinatal Cardiology, Guy's Hospital, London, UK.
Lancet. 1991 Apr 20;337(8747):959-61. doi: 10.1016/0140-6736(91)91582-f.
Hypoplastic left heart syndrome was diagnosed prenatally and confirmed in 105 fetuses since 1983 at a regional referral centre. An increased detection rate since 1988 is probably related to increased experience in the use of a four-chamber view of the fetal heart during routine obstetric ultrasound scanning. When the diagnosis was made sufficiently early, most parents chose to terminate the pregnancy after the prognosis and surgical options were explained. By contrast, after an increase in the mid 1980s, since 1988 there has been a striking fall in the number of newborn babies with hypoplastic left heart syndrome treated at a supraregional referral centre. More widespread use of four-chamber cardiac screening during routine fetal ultrasonography may reduce the number of newborn babies with hypoplastic left heart syndrome--a factor which should be taken into account when the likely requirements for neonatal cardiac transplantation facilities are calculated.
自1983年以来，在某地区转诊中心对105例胎儿进行了产前诊断并确诊为左心发育不全综合征。1988年以来检出率的增加可能与在常规产科超声扫描中使用胎儿心脏四腔心切面的经验增加有关。如果诊断足够早，在向父母解释预后和手术方案后，大多数父母会选择终止妊娠。相比之下，在20世纪80年代中期有所增加之后，自1988年以来，在一个区域以上转诊中心接受治疗的患有左心发育不全综合征的新生儿数量显著下降。在常规胎儿超声检查中更广泛地使用心脏四腔心筛查可能会减少患有左心发育不全综合征的新生儿数量——在计算新生儿心脏移植设施的可能需求时应考虑这一因素。
