Laing M E, Moloney F J, Kay E W, Conlon P, Murphy G M
Department of Dermatology, Beaumont Hospital, Dublin, Ireland.
Clin Exp Dermatol. 2006 Sep;31(5):662-4. doi: 10.1111/j.1365-2230.2006.02188.x.
The characteristics of malignant melanoma arising in transplant patients are not clearly delineated. We describe clinical and histological features of malignant melanoma in five transplant patients. All transplant patients with melanoma arising post-transplantation had a previous history of skin cancer. Two had a history of internal organ malignancy. Three patients had thick malignant melanomas (Clark level III or higher, or >0.76 mm Breslow thickness). Lymph-node metastases occurred in one patient with cutaneous melanoma. Local cutaneous metastases occurred in one patient. Mean duration from transplantation to melanoma was 15.6 years. Two cases of aggressive metastatic melanoma responded well to cessation of immunosuppression. Three patients with nonmetastatic disease responded well to conventional complete excision and continuation of immunosuppression.
移植患者中发生的恶性黑色素瘤的特征尚未明确界定。我们描述了5例移植患者中恶性黑色素瘤的临床和组织学特征。所有移植后发生黑色素瘤的患者既往均有皮肤癌病史。2例有内脏恶性肿瘤病史。3例患者患有厚的恶性黑色素瘤（克拉克分级为III级或更高，或 Breslow厚度>0.76 mm）。1例皮肤黑色素瘤患者发生了淋巴结转移。1例患者发生了局部皮肤转移。从移植到黑色素瘤的平均时间为15.6年。2例侵袭性转移性黑色素瘤患者在停止免疫抑制后反应良好。3例非转移性疾病患者对传统的完全切除和继续免疫抑制反应良好。
