Fandrey Joachim, Gorr Thomas A, Gassmann Max
Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany.
Cardiovasc Res. 2006 Sep 1;71(4):642-51. doi: 10.1016/j.cardiores.2006.05.005. Epub 2006 May 10.
Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation.
在氧气供应有限的情况下，氧稳态需要缺氧依赖的基因调控。转录因子复合物缺氧诱导因子1（HIF-1）已被公认为介导适应性基因反应以确保能量供应恢复的主要调节因子。本综述将重点关注在理解缺氧诱导的细胞反应方面的最新进展，特别是关于细胞氧感应以充分控制HIF-1激活的方面。
