Cheung Lim Kwong, Zheng Li Wu, Ma Li
Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry, the University of Hong Kong, Hong Kong, China.
J Craniomaxillofac Surg. 2006 Jul;34(5):263-9. doi: 10.1016/j.jcms.2006.02.004. Epub 2006 Jun 14.
The expression of bone morphogenetic proteins can be regarded as an indicator for biological interaction in distraction osteogenesis. It was hypothesized that different distraction rates may produce different patterns of BMP expression.
This study compared the expression of BMP-2, -4 and -7 at routine (0.9mm once daily) and rapid (2.7mm once daily) distraction rates using the rabbit mandibular lengthening model. Mandibular samples were harvested at days 1, 7 and 14 of consolidation.
The expression of BMP-2 and BMP-4 was found throughout the experiment, their expression intensity and location being essentially similar, whereas BMP-7 had not been expressed. Expression of BMP-2 and -4 was more intense at the routine distraction rate than at the rapid distraction rate.
BMP-7 had no expression during the consolidation period of mandibular distraction. The change in the mechanical environment created by different distraction rates led to different expression of BMP-2 and -4. In the early consolidation stage the biological environment for bone formation created by distraction at a routine rate was superior to that created by the rapid distraction rate.
骨形态发生蛋白的表达可被视为牵张成骨中生物相互作用的一个指标。据推测，不同的牵张速率可能会产生不同的骨形态发生蛋白表达模式。
本研究使用兔下颌骨延长模型，比较了常规牵张速率（每日一次，每次0.9毫米）和快速牵张速率（每日一次，每次2.7毫米）下骨形态发生蛋白-2、-4和-7的表达情况。在愈合的第1天、第7天和第14天采集下颌骨样本。
在整个实验过程中均发现了骨形态发生蛋白-2和-4的表达，它们的表达强度和位置基本相似，而骨形态发生蛋白-7未表达。骨形态发生蛋白-2和-4在常规牵张速率下的表达比在快速牵张速率下更强烈。
在下颌骨牵张的愈合期，骨形态发生蛋白-7没有表达。不同牵张速率所产生的力学环境变化导致了骨形态发生蛋白-2和-4的不同表达。在早期愈合阶段，常规牵张速率下牵张所创造的骨形成生物环境优于快速牵张速率下所创造的环境。
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