大鼠脑中多巴胺能突触前和突触后元件的个体发生变化：喹吡罗和舒必利的作用。

Ontogenetic changes in dopaminergic pre and postsynaptic elements in rat brain: effects of quinpirole and sulpiride.

作者信息

McDougall S A, Bardo M T

机构信息

Department of Psychology, University of Kentucky, Lexington 40506.

出版信息

Neuropharmacology. 1991 May;30(5):531-4. doi: 10.1016/0028-3908(91)90017-6.

DOI:10.1016/0028-3908(91)90017-6

PMID:1678147

Abstract

The effects of quinpirole and sulpiride on dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and accumulation of dihydroxyphenylalanine (DOPA) after inhibition of DOPA decarboxylase were determined for the striatum and tegmentum of 11- and 17-day-old rat pups. In both 11- and 17-day-olds, sulpiride enhanced striatal DOPAC and DOPA accumulation; whereas, quinpirole decreased DOPAC levels and increased DA levels. In the tegmentum, sulpiride enhanced DOPA accumulation in the 11-day-olds only. 3H-spiroperidol binding sites were also measured in the striatum, nucleus accumbens, tegmentum, medial frontal cortex, and the hippocampo-entorhinal area of 11- and 17-day-old pups. Age-dependent increases in binding site density were found in the striatum and nucleus accumbens.

摘要

测定了喹吡罗和舒必利对11日龄和17日龄幼鼠纹状体和被盖区中多巴胺（DA）、二羟基苯乙酸（DOPAC）以及多巴脱羧酶抑制后二羟基苯丙氨酸（DOPA）积累的影响。在11日龄和17日龄幼鼠中，舒必利均增强了纹状体中DOPAC和DOPA的积累；而喹吡罗降低了DOPAC水平并升高了DA水平。在被盖区，舒必利仅增强了11日龄幼鼠的DOPA积累。还测量了11日龄和17日龄幼鼠纹状体、伏隔核、被盖区、内侧额叶皮质以及海马-内嗅区的3H-螺哌啶结合位点。在纹状体和伏隔核中发现结合位点密度存在年龄依赖性增加。