细胞生物学：Ran、有丝分裂与癌症关联
Cell biology: Ran, mitosis and the cancer connection.
作者信息
Sanderson Helen S, Clarke Paul R
机构信息
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.
出版信息
Curr Biol. 2006 Jun 20;16(12):R466-8. doi: 10.1016/j.cub.2006.05.032.
PMID:16782004
Abstract
The small GTPase Ran has been shown to regulate HURP, a protein that interacts with several mitotic spindle assembly factors. This discovery sheds new light on the role of Ran in the fidelity of mitosis and in cancer.
摘要
小GTP酶Ran已被证明可调节HURP，HURP是一种与多种有丝分裂纺锤体组装因子相互作用的蛋白质。这一发现为Ran在有丝分裂保真度及癌症中的作用提供了新的线索。
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