Barad M, Erlebacher A, McGinnis W
Department of Human Genetics, Yale University, New Haven, Connecticut 06511.
Dev Genet. 1991;12(3):206-11. doi: 10.1002/dvg.1020120305.
H2.0, a homeobox gene identified by homology to the Sex combs reduced homeobox of Drosophila, is expressed in all the cellular precursors of the visceral musculature. By analogy to the essential function of most other known homeobox genes in determining the fate of cells where they are expressed, we hypothesized that mutation of H2.0 would disrupt gut muscle development. In this paper, we show that a small deletion, which eliminates H2.0, has no detectable effect on normal gut morphogenesis, visceral muscle actin organization, or larval peristalsis.
H2.0是通过与果蝇的性梳减少同源异型框基因同源性鉴定出的一个同源异型框基因，在内脏肌肉组织的所有细胞前体中表达。鉴于大多数其他已知同源异型框基因在决定其表达细胞命运方面的重要功能，我们推测H2.0的突变会破坏肠道肌肉发育。在本文中，我们表明一个消除H2.0的小缺失对正常肠道形态发生、内脏肌动蛋白组织或幼虫蠕动没有可检测到的影响。
