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[高龄老年人高血压的管理]

[Management of hypertension in the very elderly].

作者信息

Hanon Olivier

机构信息

Service de gériatrie, Hôpital Broca, CHU Cochin Port-Royal, Université René Descartes, Paris V, 54/56 Rue Pascal, 75013 Paris.

出版信息

Presse Med. 2006 Jun;35(6 Pt 2):1047-53. doi: 10.1016/s0755-4982(06)74746-7.

Abstract

The prevalence of hypertension in persons aged 80 years or older is about 70%. Recent studies in this population show the benefits of antihypertensive therapy, especially for stroke prevention. Accurate determination of blood pressure requires the use of ambulatory measurement methods or self-measurement at home because the frequency of "white coat" hypertension increases with age. It is essential to distinguish patients with sustained hypertension, who need antihypertensive drugs, from those with white coat hypertension, for whom treatment is not justified and may be dangerous because of the risk of hypotension. The objective of antihypertensive treatment is to decrease blood pressure to less than 140/90 mmHg for those aged 60 to 80 years and to decrease systolic pressure to less than 150 mmHg in those older than 80 years, without orthostatic hypotension. Any class of antihypertensive drugs can be used to start treatment, although in the absence of specific indications due to concomitant diseases, thiazide diuretics or calcium channel blockers are preferred for initial treatment. Most often, very elderly hypertensive patients will require two antihypertensive drugs for adequate blood pressure control. Generally their regimen should not include more than 3 antihypertensive drugs (including a thiazide diuretic).

摘要

80岁及以上人群中高血压的患病率约为70%。近期针对该人群的研究显示了抗高血压治疗的益处,尤其是在预防中风方面。由于“白大衣”高血压的发生率随年龄增长而增加,因此准确测定血压需要采用动态测量方法或在家自行测量。区分需要使用抗高血压药物的持续性高血压患者与白大衣高血压患者至关重要,对于后者,治疗不合理且可能因低血压风险而危险。抗高血压治疗的目标是,60至80岁的患者血压降至140/90 mmHg以下,80岁以上的患者收缩压降至150 mmHg以下,且无体位性低血压。尽管在没有因合并症导致的特定指征时,噻嗪类利尿剂或钙通道阻滞剂首选用于初始治疗,但任何一类抗高血压药物均可用于开始治疗。大多数高龄高血压患者通常需要两种抗高血压药物才能充分控制血压。一般来说,他们的治疗方案不应包括超过3种抗高血压药物(包括一种噻嗪类利尿剂)。

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