• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一名糖皮质激素受体数量增加的儿童在短期口服和吸入类固醇后发生的股骨头坏死。

Osteonecrosis of the hip after short courses of oral and inhaled steroids in a child with an increased number of glucocorticoid receptors.

作者信息

Drigo Ilenia, Saccari Alessia, Barbi Egidio, Bartoli Fiora, Decorti Giuliana, Ventura Alessandro

机构信息

Department of Reproductive and Developmental Science and IRCCS, Istituto per I'Infanzia Burlo Garofolo, Clinica Pediatrica, Trieste, Italy.

出版信息

Eur J Pediatr. 2006 Dec;165(12):913-5. doi: 10.1007/s00431-006-0197-x. Epub 2006 Jun 17.

DOI:10.1007/s00431-006-0197-x
PMID:16783583
Abstract

We report an unusual case of osteonecrosis of the femoral head associated with recurrent myopathy and bone abnormalities in a two-year-old girl, in whom symptoms occurred after a ten-day course of oral betamethasone for infectious wheezy bronchitis, and eventually recurred and were worsened by topical treatment; a hypersensitivity to glucocorticoids is hypothesised.

摘要

我们报告了一例罕见的股骨头坏死病例，该病例发生在一名两岁女童身上，伴有复发性肌病和骨骼异常。患儿因感染性喘息性支气管炎接受了为期十天的口服倍他米松治疗，之后出现症状，最终症状复发，且局部治疗使其加重；推测其对糖皮质激素过敏。

相似文献

1
Osteonecrosis of the hip after short courses of oral and inhaled steroids in a child with an increased number of glucocorticoid receptors.一名糖皮质激素受体数量增加的儿童在短期口服和吸入类固醇后发生的股骨头坏死。
Eur J Pediatr. 2006 Dec;165(12):913-5. doi: 10.1007/s00431-006-0197-x. Epub 2006 Jun 17.
2
Avascular necrosis of the femoral heads after single corticosteroid injection.单次注射皮质类固醇后股骨头缺血性坏死
CMAJ. 2006 Jul 4;175(1):31. doi: 10.1503/cmaj.051638.
3
Femoral head osteonecrosis after topical corticosteroid therapy.局部应用皮质类固醇治疗后股骨头坏死
Clin Exp Rheumatol. 2001 Mar-Apr;19(2):233.
4
Corticosteroids in pregnancy and osteonecrosis of the femoral head.孕期使用皮质类固醇与股骨头坏死
Obstet Gynecol. 1999 Nov;94(5 Pt 2):848. doi: 10.1016/s0029-7844(99)00538-4.
5
Osteonecrosis 15 years after femoral neck fracture and long-term low-dose inhaled corticosteroid therapy.股骨颈骨折及长期低剂量吸入性糖皮质激素治疗15年后发生骨坏死。
Joint Bone Spine. 2004 May;71(3):237-9. doi: 10.1016/S1297-319X(03)00115-5.
6
[Steroid-induced myopathy (apropos of an observation associated with bilateral aseptic necrosis of the femoral head)].[类固醇诱导性肌病（关于一例与双侧股骨头无菌性坏死相关的观察病例）]
Rev Clin Esp. 1976 Mar 31;140(6):585-8.
7
MRI-detected bone marrow changes within 3 weeks after initiation of high-dose corticosteroid therapy: a possible change preceding the subsequent appearance of low-intensity band in femoral head osteonecrosis.高剂量糖皮质激素治疗开始后3周内MRI检测到的骨髓变化：可能是股骨头坏死中随后出现低强度带之前的一种变化。
Rheumatol Int. 2015 Nov;35(11):1909-12. doi: 10.1007/s00296-015-3346-6. Epub 2015 Aug 22.
8
[Osteonecrosis following short-term, high-dosage steroid therapy].[短期大剂量类固醇治疗后发生的骨坏死]
Schweiz Med Wochenschr. 1991 May 4;121(18):635-41.
9
Bilateral femoral avascular necrosis in a man with psoriasis: responsibility of topical corticosteroids and role of cyclosporine.
Dermatology. 2001;203(4):356-7. doi: 10.1159/000051794.
10
Bilateral femoral head avascular necrosis with a very low dose of oral corticosteroid used for panhypopituitarism.双侧股骨头缺血性坏死，使用极低剂量口服糖皮质激素治疗全垂体功能减退症。
BMJ Case Rep. 2016 Jan 13;2016:bcr2015212803. doi: 10.1136/bcr-2015-212803.

引用本文的文献

1
Concurrence of osteonecrosis and steroid myopathy secondary to oral steroid therapy in a patient with ABCB1 gene polymorphisms: A case report.口服类固醇治疗患者中 ABCB1 基因突变与类固醇肌病并发性骨坏死：病例报告
Front Endocrinol (Lausanne). 2022 Oct 7;13:1016687. doi: 10.3389/fendo.2022.1016687. eCollection 2022.
2
Osteonecrosis of the Femoral Head in an Adolescent on Long-Term Inhalational Corticosteroids.一名长期吸入皮质类固醇的青少年的股骨头坏死
Case Rep Pediatr. 2017;2017:6969787. doi: 10.1155/2017/6969787. Epub 2017 Feb 28.
3
Inhaled corticosteroids and bone health.

本文引用的文献

1
Glucocorticoid resistance and hypersensitivity.糖皮质激素抵抗与超敏反应。
Endocrinol Metab Clin North Am. 2005 Jun;34(2):315-26, viii. doi: 10.1016/j.ecl.2005.02.002.
2
Oral prednisolone in the acute management of children age 6 to 35 months with viral respiratory infection-induced lower airway disease: a randomized, placebo-controlled trial.口服泼尼松龙用于6至35个月大的病毒感染性下呼吸道疾病患儿的急性治疗：一项随机、安慰剂对照试验。
J Pediatr. 2003 Dec;143(6):725-30. doi: 10.1067/S0022-3476(03)00498-0.
3
Efficacy of a short course of parent-initiated oral prednisolone for viral wheeze in children aged 1-5 years: randomised controlled trial.
吸入性糖皮质激素与骨骼健康。
Open Respir Med J. 2014 Jan 31;8:85-92. doi: 10.2174/1874306401408010085. eCollection 2014.
4
Steroid induced osteonecrosis: An analysis of steroid dosing risk.类固醇诱导性骨坏死：类固醇剂量风险分析。
Autoimmun Rev. 2010 Sep;9(11):721-43. doi: 10.1016/j.autrev.2010.06.007. Epub 2010 Jul 9.
家长主动给予短期口服泼尼松龙治疗1-5岁儿童病毒性喘息的疗效：随机对照试验。
Lancet. 2003 Nov 1;362(9394):1433-8. doi: 10.1016/S0140-6736(03)14685-5.
4
Osteonecrosis of the hip (Legg-Calvé-Perthes disease) in human immunodeficiency virus-infected children.人类免疫缺陷病毒感染儿童的髋关节骨坏死（Legg-Calvé-Perthes病）
Pediatrics. 2002 May;109(5):E74-4. doi: 10.1542/peds.109.5.e74.
5
Bilateral femoral avascular necrosis in a man with psoriasis: responsibility of topical corticosteroids and role of cyclosporine.
Dermatology. 2001;203(4):356-7. doi: 10.1159/000051794.
6
Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance.原发性皮质醇抵抗患者糖皮质激素受体基因两个新突变的特征分析。
Clin Endocrinol (Oxf). 2001 Sep;55(3):363-71. doi: 10.1046/j.1365-2265.2001.01323.x.
7
Effect of glucocorticoid therapy on glucocorticoid receptors in children with autoimmune diseases.
Pediatr Res. 2001 Jan;49(1):130-5. doi: 10.1203/00006450-200101000-00025.
8
Normocortisolemic Cushing's syndrome initially presenting with increased glucocorticoid receptor numbers.正常皮质醇血症性库欣综合征最初表现为糖皮质激素受体数量增加。
J Clin Endocrinol Metab. 2000 Jan;85(1):14-21. doi: 10.1210/jcem.85.1.6220.
9
A patient with hypocortisolism and Cushing's syndrome-like manifestations: cortisol hyperreactive syndrome.一名患有皮质醇减少症并伴有库欣综合征样表现的患者：皮质醇高反应综合征。
J Clin Endocrinol Metab. 1990 Mar;70(3):729-37. doi: 10.1210/jcem-70-3-729.