Lescun Timothy B, Vasey James R, Ward Michael P, Adams Stephen B
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47909-1248, USA.
J Am Vet Med Assoc. 2006 Jun 15;228(12):1922-9. doi: 10.2460/javma.228.12.1922.
OBJECTIVE-To determine clinical findings, complications, and outcome of septic synovitis in which continuous intrasynovial antimicrobial infusion (CIAI) was used for local antimicrobial delivery in horses. DESIGN-Retrospective case series. Animals-22 adult horses and 9 foals (horses<1 year of age). PROCEDURES-Records of horses with septic synovitis that had CIAI during treatment were reviewed. The association between clinical variables and whether horses performed their intended use following treatment was determined. RESULTS-42 synovial cavities were treated via CIAI. Twenty-nine cases were chronic (>7 days) in nature, 15 had been refractory to standard treatments, and 13 synovial infections had associated osteomyelitis. Mean duration from infection to initiation of CIAI was 19.7 days, and mean duration of CIAI was 6.1 days. Temporary discharge from the catheter site at the time of removal was evident in 8 horses. Dysfunction of the infusion system occurred in 2 horses and was corrected during the course of treatment. No long-term complications were reported. Thirty-nine (93%) synovial infections in 29 (94%) horses were resolved. Twenty adult horses and 8 foals were discharged from the hospital, and 19 of 24 horses with long-term follow-up performed their intended use. CONCLUSIONS AND CLINICAL RELEVANCE-CIAI was a useful adjunctive treatment for septic synovitis and allowed intrasynovial antimicrobial delivery into a variety of synovial cavities.
目的——确定在马的化脓性滑膜炎中，采用持续滑膜内抗菌药物输注（CIAI）进行局部抗菌药物给药的临床发现、并发症及转归。
设计——回顾性病例系列研究。
动物——22匹成年马和9匹驹（年龄<1岁的马）。
方法——对治疗期间采用CIAI的化脓性滑膜炎马匹的记录进行回顾。确定临床变量与治疗后马匹能否按预期用途使用之间的关联。
结果——通过CIAI治疗了42个滑膜腔。29例为慢性（>7天）病例，15例对标准治疗无效，13例滑膜感染伴有骨髓炎。从感染到开始CIAI的平均时间为19.7天，CIAI的平均持续时间为6.1天。8匹马在拔除导管时导管部位出现暂时渗出。2匹马出现输注系统功能障碍，在治疗过程中得到纠正。未报告长期并发症。29匹马中的39例（93%）滑膜感染得到解决。20匹成年马和8匹驹出院，24匹接受长期随访的马中有19匹能按预期用途使用。
结论及临床意义——CIAI是化脓性滑膜炎的一种有用辅助治疗方法，可将滑膜内抗菌药物输送到各种滑膜腔。
