Wilde Andrew
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
J Cell Biol. 2006 Jun 19;173(6):829-31. doi: 10.1083/jcb.200605150.
RanGTP has a central role in spindle assembly, but the Ran-regulated factors required to initiate spindle bipolarity and stabilize MT growth toward the chromosomes remain unknown. However, three recent papers (Koffa et al., 2006; Sillje et al., 2006; Wong and Fang, 2006) have identified a single factor, HURP, that may encompass both of these properties.
RanGTP在纺锤体组装中起核心作用，但启动纺锤体双极性并稳定微管向染色体生长所需的Ran调节因子仍不清楚。然而，最近的三篇论文（Koffa等人，2006年；Sillje等人，2006年；Wong和Fang，2006年）确定了一个单一因子HURP，它可能兼具这两种特性。
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