有丝分裂纺锤体的机制与分子

Mechanisms and molecules of the mitotic spindle.

作者信息

Gadde Sharat, Heald Rebecca

机构信息

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720-3200, USA.

出版信息

Curr Biol. 2004 Sep 21;14(18):R797-805. doi: 10.1016/j.cub.2004.09.021.

DOI:10.1016/j.cub.2004.09.021

PMID:15380094

Abstract

In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is required for the faithful transmission of the genome to the two daughter cells during division. This process is facilitated by the intrinsic polarity and dynamic properties of microtubules and involves many proteins that modulate microtubule organization and stability. Recent work has begun to uncover the molecular mechanisms behind these dynamic events. Here we describe current models and discuss some of the complex repertoire of factors required for spindle assembly and chromosome segregation.

摘要

在所有真核生物中，微管细胞骨架形成双极纺锤体的形态发生过程，对于基因组在细胞分裂期间准确传递到两个子细胞是必需的。微管的内在极性和动态特性促进了这一过程，并且涉及许多调节微管组织和稳定性的蛋白质。最近的研究开始揭示这些动态事件背后的分子机制。在这里，我们描述当前的模型，并讨论纺锤体组装和染色体分离所需的一些复杂的因子组合。