Lachowicz A, Pawlikowski M
Department of Experimental Endocrinology, Medical Academy of Lodz, Poland.
Biochem Biophys Res Commun. 1991 Aug 15;178(3):1492-7. doi: 10.1016/0006-291x(91)91062-h.
The effects of somatostatin-14 and its biologically active analogs, RC-160 and SMS 201-995, on (Ca,Mg)ATPase activity in vitro were studied in homogenates of anterior pituitary cells. It was found that somatostatin inhibited the (Ca,Mg)ATPase activity in the anterior pituitary and somatostatin analogs exerted slight biphasic effects on the calcium pump activity. The effects of specific brain (Ca,Mg)ATPase inhibitors, VOSO4 and LaCl3, were also studied in vitro. Neither VOSO4 nor LaCl3 enhance the inhibition of calcium pump activity caused by somatostatin. It is suggested that somatostatin may mediate its action in pituitary cells, among others, by the regulation of (Ca,Mg)ATPase activity.
研究了生长抑素 -14及其生物活性类似物RC -160和SMS 201 -995对垂体前叶细胞匀浆中（钙，镁）ATP酶活性的体外作用。发现生长抑素抑制垂体前叶中的（钙，镁）ATP酶活性，且生长抑素类似物对钙泵活性产生轻微的双相作用。还在体外研究了特定脑（钙，镁）ATP酶抑制剂VOSO4和LaCl3的作用。VOSO4和LaCl3均未增强生长抑素对钙泵活性的抑制作用。提示生长抑素可能通过调节（钙，镁）ATP酶活性等方式在垂体细胞中介导其作用。
