Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.
作者信息
Davies Stephen G, Garner A Christopher, Goddard Euan C, Kruchinin Dennis, Roberts Paul M, Rodriguez-Solla Humberto, Smith Andrew D
机构信息
Department of Organic Chemistry, University of Oxford, Chemical Research Laboratory, Mansfield Road, Oxford, UKOX1 3TA.
出版信息
Chem Commun (Camb). 2006 Jul 5(25):2664-6. doi: 10.1039/b604835h. Epub 2006 May 18.
DOI:10.1039/b604835h
PMID:16786080
Abstract
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e.
摘要
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