Okudan Nilsel, Acar Hasan, Gökbel Hakki, Mevlitoğlu Inci, Sari Fatih
Department of Physiology, Meram Faculty of Medicine, Selçuk University, 42080 Konya, Turkey.
Arch Dermatol Res. 2006 Aug;298(3):127-30. doi: 10.1007/s00403-006-0669-x. Epub 2006 Jun 20.
The present study was aimed to evaluate serum leptin level and the frequency of oligopolymorphic codon 25 (CAA/CAG) of Ob gene in Behcet's disease. Eighty-seven patients with Behcet's disease and 85 healthy controls with matched age, gender and body mass index were included in the study. Serum leptin level was determined and genotype of codon 25 of Ob gene was performed by using the PCR amplification after DNA extraction. Serum leptin concentration of the patients with Behcet's disease (23.8 +/- 22.8 ng/ml) was higher than that of the control groups (17.1 +/- 14.7 ng/ml). The patients with Behcet's disease and control subjects showed CAA/CAA genotype, indicating the presence of no polymorphism. Neither Behcet's disease nor serum leptin level was found to be related to codon 25 polymorphism. We concluded that leptin 25CAG polymorphism is not associated with Behcet's disease and serum leptin level.
本研究旨在评估白塞病患者血清瘦素水平及Ob基因寡聚多态密码子25（CAA/CAG）的出现频率。本研究纳入了87例白塞病患者以及85例年龄、性别和体重指数相匹配的健康对照者。测定血清瘦素水平，并在DNA提取后通过PCR扩增对Ob基因密码子25进行基因分型。白塞病患者的血清瘦素浓度（23.8±22.8 ng/ml）高于对照组（17.1±14.7 ng/ml）。白塞病患者和对照者均表现为CAA/CAA基因型，表明不存在多态性。未发现白塞病及血清瘦素水平与密码子25多态性相关。我们得出结论，瘦素25CAG多态性与白塞病及血清瘦素水平无关。
