Modrzyński Marek, Mazurek Henryk, Zawisza Edward
Poradnia Alergologiczna NZOZ Euromedica, Grudziadz.
Przegl Lek. 2005;62(12):1337-42.
In addition to allergen elimination, specific immunotherapy remains the only recognized causal treatment of allergic diseases. Nevertheless, there are no commonly accepted parameters and tests allowing for the evaluation and prediction of its efficacy. The aim of this study was to evaluate the results of readily available supplemental allergy tests and to attempt to associate those findings with the outcome of therapy for desensitized patients.
This study was conducted in a group of 22 patients receiving specific immunotherapy for perennial allergic rhinitis to dust mites. The results of skin prick tests, sIgE levels, nasal eosinophilia levels as well as specific nasal provocation tests measured by acoustic rhinometry were compared prior to desensitization and two years following the therapy. The control group comprised 17 allergic patients treated without immunotherapy.
Apart from the confirmation of immunotherapy efficacy, a positive correlation between its results and the results of the nasal provocation test (correlation coefficient r = 0.85) were demonstrated in this study. No relationship was however found between the obtained result and the results of skin prick tests (r = 0.57) and serum sIgE levels (r = 0.59) or nasal eosinophilia (r = 0.57). The result of acoustic rhinometry corresponded well with clinical manifestations observed in nasal provocation tests.
The specific nasal provocation test is an easy method that may be used for monitoring the efficacy of immunotherapy, and acoustic rhinometry is a good method for measuring its results.
除了消除过敏原外，特异性免疫疗法仍然是唯一被认可的过敏性疾病的病因治疗方法。然而，目前尚无普遍接受的参数和检测方法来评估和预测其疗效。本研究的目的是评估易于获得的补充过敏检测结果，并尝试将这些结果与脱敏治疗患者的治疗结果相关联。
本研究对22例因常年性变应性鼻炎接受针对尘螨的特异性免疫治疗的患者进行。比较了脱敏治疗前和治疗两年后皮肤点刺试验、特异性IgE水平、鼻嗜酸性粒细胞水平以及通过鼻声反射测量的特异性鼻激发试验结果。对照组包括17例未接受免疫治疗的变应性患者。
除了证实免疫治疗的疗效外，本研究还证实了其结果与鼻激发试验结果之间存在正相关（相关系数r = 0.85）。然而，未发现所获结果与皮肤点刺试验结果（r = 0.57）、血清特异性IgE水平（r = 0.59）或鼻嗜酸性粒细胞（r = 0.57）之间存在相关性。鼻声反射结果与鼻激发试验中观察到的临床表现吻合良好。
特异性鼻激发试验是一种可用于监测免疫治疗疗效的简便方法，鼻声反射是一种测量其结果的良好方法。
