Olkkola K T, Schwilden H
Department of Clinical Pharmacology, University of Helsinki, Finland.
Eur J Anaesthesiol. 1991 Jan;8(1):7-12.
An adaptive closed-loop control of neuromuscular block by pharmacokinetic dynamic model-based feedback is described. Mean (+/- SD) offsets from setpoints at 70, 80 and 90% neuromuscular blockade were 2.2 +/- 1.1, 1.8 +/- 0.6 and 0.4 +/- 0.4%, respectively. Correspondingly, the mean standard deviations from mean neuro-muscular blockade were 3.9 +/- 2.3, 2.7 +/- 0.6 and 1.3 +/- 0.2% and the mean average vecuronium requirements 0.5 +/- 0.2, 0.7 +/- 0.2 and 1.0 +/- 0.5 micrograms kg-1 min-1. The described closed-loop vecuronium administration system gives a solution to the problem of adapting pharmacokinetic and pharmacodynamic data to individuals when using mean data as starting values for drug therapy.
本文描述了一种基于药代动力学动态模型反馈的神经肌肉阻滞自适应闭环控制。在神经肌肉阻滞程度为70%、80%和90%时，与设定值的平均（±标准差）偏差分别为2.2±1.1%、1.8±0.6%和0.4±0.4%。相应地，神经肌肉阻滞平均值的平均标准差分别为3.9±2.3%、2.7±0.6%和1.3±0.2%，维库溴铵的平均需求量分别为0.5±0.2、0.7±0.2和1.0±0.5微克·千克⁻¹·分钟⁻¹。所描述的维库溴铵闭环给药系统为在将平均数据用作药物治疗起始值时，使药代动力学和药效学数据适应个体的问题提供了解决方案。
