α2肾上腺素能受体而非咪唑受体介导猫骶髓反射的抑制。
Alpha 2-adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat.
作者信息
Downie J W, Espey M J, Gajewski J B
机构信息
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
出版信息
Eur J Pharmacol. 1991 Mar 26;195(2):301-4. doi: 10.1016/0014-2999(91)90551-z.
In chloralose-anaesthesized cats, clonidine, an alpha 2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole alpha 2-adrenoceptor agonist, and was reversed by SK & F 86466, a non-imidazole alpha 2-adrenoceptor antagonist. These results imply that clonidine's action on this reflex related to urinary sphincter function is mediated by alpha 2-adrenoceptors and is not dependent on an imidazole structure.
在使用水合氯醛麻醉的猫中，可乐定（一种带有咪唑环的α2肾上腺素能受体激动剂）可抑制阴部神经反射活动。胍那苄（一种非咪唑类α2肾上腺素能受体激动剂）可模拟可乐定对这种复合动作电位反应的抑制作用，而SK & F 86466（一种非咪唑类α2肾上腺素能受体拮抗剂）可逆转该作用。这些结果表明，可乐定对这种与尿道括约肌功能相关的反射的作用是由α2肾上腺素能受体介导的，且不依赖于咪唑结构。
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