Paraskevas Kosmas I, Liapis Christos D, Mikhailidis Dimitri P
Research Fellow, Department of Vascular Surgery, Athens University Medical School, Greece.
Curr Drug Targets. 2006 Jun;7(6):761-71. doi: 10.2174/138945006777435371.
Leptin seems to regulate various physiological mechanisms besides body weight. Leptin plays a role in vascular biology and pathology as well as renal function. In addition, leptin has been implicated in the regulation of fertility and reproduction. The effect of pharmaceutical agents on circulating plasma leptin levels has been assessed. Among the drugs investigated are glitazones, statins, fibrates, serotonin reuptake inhibitors and cannabinoid-1 receptor antagonists. Since these agents are used to treat pathological conditions there is a potential role for leptin in these states. The degree of involvement of leptin in several pathophysiological states needs to be defined to aid in the development of potentially useful therapeutic agents.
瘦素似乎除了调节体重外，还能调节各种生理机制。瘦素在血管生物学和病理学以及肾功能方面发挥作用。此外，瘦素还与生育和生殖的调节有关。已经评估了药物制剂对循环血浆瘦素水平的影响。所研究的药物包括格列酮类、他汀类、贝特类、5-羟色胺再摄取抑制剂和大麻素-1受体拮抗剂。由于这些药物用于治疗病理状况，瘦素在这些状态下可能发挥作用。需要确定瘦素在几种病理生理状态中的参与程度，以帮助开发潜在有用的治疗药物。
