Bono G, Sinforiani E, Merlo P, Belloni G, Soldati M, Gelso E
Third Department of Neurology, Intituto Ricovero e Cura a Carattesre Scientifico (IRCCS) C. Mondino, University of Pavia, Italy.
Int J Clin Pharmacol Res. 1991;11(1):35-40.
The effects of metadoxine (pyrrolidone carboxylate of pyridoxine), a compound with central benzodiazepine-like properties, were evaluated in two groups of chronic alcoholics (inpatients) presenting a mild withdrawal syndrome. According to a double-blind study design 20 patients received metadoxine 900 mg twice daily eluted in 500 ml of saline infusion, while 20 (the control group) were given 500 ml of saline infusion twice daily with equivalent doses of pyridoxine (40 mg/die) every morning over a 10-day period. The results indicate that metadoxine treatment was able to control alcohol abstinence, thus allowing a reduction in the needs for standard benzodiazepine therapy. The central activity of gamma-aminobutyric acid of this compound might play a crucial role in the clinical effects demonstrated.
美他多辛（吡哆醇的吡咯烷酮羧酸盐）是一种具有中枢苯二氮䓬样特性的化合物，对两组患有轻度戒断综合征的慢性酗酒者（住院患者）进行了其效果评估。根据双盲研究设计，20名患者每天两次接受溶于500毫升生理盐水输注中的900毫克美他多辛，而20名患者（对照组）在10天时间里每天两次接受500毫升生理盐水输注，且每天早晨给予等量的吡哆醇（40毫克/日）。结果表明，美他多辛治疗能够控制戒酒，从而减少对标准苯二氮䓬疗法的需求。该化合物的γ-氨基丁酸中枢活性可能在所显示的临床效果中起关键作用。
