Duquesnoy R J
Birth Defects Orig Artic Ser. 1975;11(1):536-43.
Pituitary dwarf mutants of the Snell-Bagg and Ames mouse strains develop severe immunodeficiency of the thymus-dependent system which frequently leads to a fatal wasting syndrome. This immunodeficiency is a consequence of defective pituitary influences which will cause 1) an inadequate production of immunocompetent cells due to a central developmental defect primarily affecting the thymus and 2) the inability of immunocompetent cells to undergo a rapid and efficient antigen-induced proliferation and differentiation into antibody-forming cells. The relevance of the dwarf mouse model to a possible association between human immunodeficiency and endocrine disease is briefly discussed.
斯奈尔-巴格和艾姆斯小鼠品系的垂体性侏儒突变体出现严重的胸腺依赖性系统免疫缺陷，常导致致命的消瘦综合征。这种免疫缺陷是垂体影响缺陷的结果，这将导致：1）由于主要影响胸腺的中枢发育缺陷，免疫活性细胞产生不足；2）免疫活性细胞无法迅速有效地进行抗原诱导的增殖并分化为抗体形成细胞。本文简要讨论了侏儒小鼠模型与人类免疫缺陷和内分泌疾病之间可能关联的相关性。
