Cagnacci A, Melis G B, Soldani R, Bonuccelli U, Piccini P, Napolitano A, Muratorio A, Fioretti P
Department of Obstetrics and Gynecology, University of Pisa, Italy.
Neuroendocrinology. 1991 Jun;53(6):549-55. doi: 10.1159/000125773.
The secretion of gonadotropins and the role exerted by the endogenous opioid system on luteinizing hormone (LH) secretion were investigated in 6 postmenopausal women affected by idiopathic Parkinson's disease (PD) as well as in 6 age- and weight-matched normal postmenopausal women as controls. The mean plasma follicle-stimulating hormone (FSH) and LH levels were evaluated both under basal conditions and after 20 days of conjugated estrogen administration (1.25 mg/day). At the same time, the activity of the endogenous opioid system was evaluated, as well as the LH response to the 4-hour infusion of the opioid antagonist naloxone (1.6 mg i.v. bolus followed by 1.6 mg/h). Both before and during estrogen administration, plasma FSH levels were similar in the two groups of subjects, whereas plasma LH levels were significantly lower (p less than 0.01) in parkinsonian than in control women. In each subject estrogen administration significantly blunted (p less than 0.01) plasma FSH levels. Plasma LH levels were reduced only in controls (p less than 0.05), but not in women with PD. In each subject, before estrogen administration, the plasma LH levels did not vary during naloxone infusion. In control women after 20 days of estrogen administration, the plasma LH levels significantly increased during naloxone infusion (p less than 0.01). By contrast, in women with PD, conjugated estrogens failed to restore the LH response to naloxone. The present results suggest that the neurotransmitter mechanisms, which regulate LH secretion, are altered, and, in particular, the activity of the endogenous opioid system is deficient in women with PD.
对6名患有特发性帕金森病（PD）的绝经后女性以及6名年龄和体重匹配的正常绝经后女性作为对照，研究了促性腺激素的分泌以及内源性阿片系统对黄体生成素（LH）分泌的作用。在基础条件下以及给予结合雌激素（1.25mg/天）20天后，评估平均血浆促卵泡激素（FSH）和LH水平。同时，评估内源性阿片系统的活性以及LH对阿片拮抗剂纳洛酮4小时输注（静脉推注1.6mg，随后1.6mg/小时）的反应。在给予雌激素之前和期间，两组受试者的血浆FSH水平相似，而帕金森病患者的血浆LH水平显著低于对照组女性（p<0.01）。在每个受试者中，给予雌激素显著降低了血浆FSH水平（p<0.01）。血浆LH水平仅在对照组中降低（p<0.05），而在PD女性中未降低。在每个受试者中，在给予雌激素之前，纳洛酮输注期间血浆LH水平没有变化。在给予雌激素20天后的对照女性中，纳洛酮输注期间血浆LH水平显著升高（p<0.01）。相比之下，在PD女性中，结合雌激素未能恢复LH对纳洛酮的反应。目前的结果表明，调节LH分泌的神经递质机制发生了改变，特别是PD女性的内源性阿片系统活性不足。
