Johansen B, Bech K
Department of Surgical Gastroenterology, Odense University Hospital, Denmark.
Eur Surg Res. 1991;23(1):51-7. doi: 10.1159/000129136.
The purpose of the present study was to evaluate the effects of both intra-arterial and intravenous infusions of somatostatin, serotonin (5-hydroxytryptamine) and isoprenaline beta 1- + beta 2-adrenoceptor agonist) on gastric acid and pepsin secretion in conscious dogs with a gastric fistula. The drugs mentioned have been examined earlier for effects on gastric secretion in vivo during intravenous infusions and these effects could be hampered by the possible indirect mechanism of action as well as the different kinetics of metabolism. A catheter (vascular access port) allowed repeatedly gastric intra-arterial infusions. Somatostatin and serotonin possessed inhibitory effects on gastric acid and pepsin secretion and were without significant differences between the analyzed ways of administration. Intra-arterial infusion, isoprenaline possessed less potent inhibitory effects on gastric secretion: the effects were significant for pepsin secretion but were nonsignificant for acid secretion. The results suggest the mechanism of action of isoprenaline, somatostatin and sertonin to diverge, and for somatostatin and serotonin it was independent of the route of administration.
本研究的目的是评估动脉内和静脉内输注生长抑素、5-羟色胺（血清素）以及β1 +β2肾上腺素能受体激动剂异丙肾上腺素对伴有胃瘘的清醒犬胃酸和胃蛋白酶分泌的影响。上述药物早前已在静脉内输注期间进行了体内对胃分泌影响的研究，而这些影响可能会受到可能的间接作用机制以及不同代谢动力学的阻碍。一根导管（血管通路端口）允许反复进行胃内动脉输注。生长抑素和血清素对胃酸和胃蛋白酶分泌具有抑制作用，且在所分析的给药方式之间无显著差异。动脉内输注时，异丙肾上腺素对胃分泌的抑制作用较弱：对胃蛋白酶分泌的影响显著，但对胃酸分泌的影响不显著。结果表明，异丙肾上腺素、生长抑素和血清素的作用机制不同，且生长抑素和血清素的作用机制与给药途径无关。
