钙调神经磷酸酶在白色念珠菌野生型菌株的应激抗性、形态发生及毒力中的作用
Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain.
作者信息
Bader Teresa, Schröppel Klaus, Bentink Stefan, Agabian Nina, Köhler Gerwald, Morschhäuser Joachim
机构信息
Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany.
出版信息
Infect Immun. 2006 Jul;74(7):4366-9. doi: 10.1128/IAI.00142-06.
Abstract
By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMP1 did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche.
摘要
借助一种新的可回收显性选择标记，我们构建了白色念珠菌野生型菌株SC5314的钙调神经磷酸酶突变体，证实了钙调神经磷酸酶介导对多种应激条件的耐受性，但白色念珠菌响应菌丝诱导环境信号转变为丝状生长的能力并不需要该酶。虽然在播散性念珠菌病小鼠模型中，钙调神经磷酸酶对白色念珠菌的毒力至关重要，但CMP1基因的缺失在阴道或肺部感染期间对毒力没有显著影响，这表明成功感染对钙调神经磷酸酶的需求取决于宿主生态位。
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