羟基自由基清除剂能否在体内预防紫外线-C直接损伤？
Can .OH scavengers protect against direct UV-C damage in vivo?
作者信息
Ewing D
机构信息
Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, PA 19102.
出版信息
Int J Radiat Biol. 1991 Sep;60(3):449-52. doi: 10.1080/09553009114552301.
It has previously been shown that ethanol and tert-butanol protect poly(U) against strand breaks from pulsed laser ultraviolet (UV) photons (lambda = 248 nm). This protection is believed to be based on a modification of direct DNA damage, not on scavenging hydroxyl radicals. In this paper, several .OH scavengers were tested in vivo with Escherichia coli DNA repair-deficient mutants to see if protection could also be demonstrated with non-laser UV photons (lambda approximately 254 nm). No protection was observed.
先前已经表明，乙醇和叔丁醇可保护聚尿苷酸（poly(U)）免受脉冲激光紫外线（UV）光子（波长λ = 248 nm）造成的链断裂。据信这种保护作用是基于对直接DNA损伤的修饰，而非清除羟基自由基。在本文中，使用大肠杆菌DNA修复缺陷型突变体在体内测试了几种羟基自由基清除剂，以观察是否也能证明非激光紫外线光子（波长λ约为254 nm）具有保护作用。未观察到保护作用。
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