Yang Minghao, An Shucheng, Gu Huaguang, Liu Zhiqiang, Ren Wei
Laboratory for Physiology and Biophysics of Excitation, College of Life Science, Shaanxi Normal University, Xian, Shaanxi, China.
Neuroreport. 2006 Jul 17;17(10):995-9. doi: 10.1097/01.wnr.0000224770.74528.d6.
The characteristics of baroreceptor firing patterns were recognized in experiment, and their dynamics revealed in theoretical analysis. During blood pressure elevation, baroreceptors gradually exhibited bursting, continuous firing, and paradoxical bursting patterns. The bursting was generated through the repeated bifurcations between rest and spiking, the continuous firing was maintained without bifurcation, and the paradoxical bursting was generated through the bifurcations between spiking and a depolarization block. Thus, the change of blood pressure spans two bifurcations and such results imply a new way for baroreceptors to encode blood pressure information. Various firing patterns were generated from the evolution of the baroreceptor system on different parts of the system's bifurcation scenario with respect to parameter I, the excitative current modulated by blood pressure.
实验中识别出了压力感受器放电模式的特征，并通过理论分析揭示了其动态特性。在血压升高期间，压力感受器逐渐呈现出爆发性、持续性放电和反常爆发性模式。爆发性放电是通过静息和放电之间的反复分叉产生的，持续性放电在没有分叉的情况下维持，反常爆发性放电是通过放电和去极化阻滞之间的分叉产生的。因此，血压变化跨越两个分叉，这些结果暗示了压力感受器编码血压信息的一种新方式。在系统分叉情景的不同部分，相对于参数I（由血压调制的兴奋性电流），压力感受器系统的演化产生了各种放电模式。
