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细菌性脑膜炎——透析导管引发的并发症。

Bacterial meningitis--complication from a dialysis catheter.

作者信息

Suresh V, McGonigle R J, Rowe P A, Tse W Y

机构信息

Department of Renal Medicine, Level 03, Derriford Hospital, Plymouth, United Kingdom.

出版信息

Clin Nephrol. 2006 Jun;65(6):457-9. doi: 10.5414/cnp65457.

Abstract

Various infective complications associated with dialysis catheter infection have been reported in the literature previously. We report a case of a hemodialysis patient presented with confusion and dysarthria secondary to Staphylococcus aureus septicemia and meningitis originating from a tunneled catheter used for providing dialysis. Blood cultures from the periphery, central venous catheter and culture of the line tip grew methicillin-sensitive Staphylococcus aureus. Lumbar puncture after CT brain confirmed Staphylococcus aureus. He was treated with high dose of an appropriate parenteral antibiotic and also removal of the infected line. In spite of optimal treatment, he died 15 days following his admission. The ideal option will be to use a definitive access like a fistula or AV graft, but in practice a significant proportion of hemodialysis patients is dialyzed with temporary or tunneled catheters all over the world, and infection poses a serious threat to dialysis patients resulting in significant mortality and morbidity. In patients with dialysis catheter-related sepsis, removal of the infected catheters and appropriate antibiotic treatment will prevent serious metastatic complications. Planning definitive access well ahead in chronic kidney disease patients and minimizing the use of temporary access is the only way forward.

摘要

先前文献中已报道了与透析导管感染相关的各种感染性并发症。我们报告一例血液透析患者,该患者因用于透析的隧道式导管引发金黄色葡萄球菌败血症和脑膜炎,出现意识模糊和构音障碍。外周血培养、中心静脉导管培养及导管尖端培养均培养出对甲氧西林敏感的金黄色葡萄球菌。头颅CT后腰椎穿刺确诊为金黄色葡萄球菌感染。给予高剂量的合适肠外抗生素治疗,并拔除感染导管。尽管进行了最佳治疗,患者入院15天后仍死亡。理想的选择是使用像动静脉内瘘或动静脉移植物这样的永久性通路,但实际上,全球相当一部分血液透析患者使用临时或隧道式导管进行透析,感染对透析患者构成严重威胁,导致显著的死亡率和发病率。对于透析导管相关败血症患者,拔除感染导管并给予适当的抗生素治疗可预防严重的转移性并发症。在慢性肾脏病患者中提前规划永久性通路并尽量减少临时通路的使用是唯一的前进方向。

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