Nabeshima Kazuki, Iwasaki Hiroshi, Koga Kaori, Hojo Hironobu, Suzumiya Junji, Kikuchi Masahiro
Department of Pathology, Fukuoka University Hospital, Fukuoka, Japan.
Pathol Int. 2006 Jul;56(7):359-67. doi: 10.1111/j.1440-1827.2006.01972.x.
Emmprin (basigin, CD147) is a cell surface glycoprotein that belongs to the immunoglobulin superfamily. It is highly expressed on the surface of tumor cells and stimulates adjacent fibroblasts or tumor cells to produce matrix metalloproteinases. Moreover, it has recently been shown that emmprin also stimulates expression of vascular endothelial growth factor and hyaluronan, which leads to angiogenesis and anchorage-independent growth/multidrug resistance, respectively. These findings have made emmprin an important molecule in tumor progression and, thus, more attractive as a target for antitumor treatment. However, other functions of emmprin, including as an activator of T cells, a chaperone for monocarboxylate transporters, a receptor for cyclophilin A and a neural recognition molecule, are also being identified in physiological and pathological conditions. Therefore, it is essential to develop specific means to control particular functions of emmprin, for which elucidation of each mechanism is crucial. This review will discuss the role of emmprin in tumor progression and recent advances in the molecular mechanisms of diverse phenomena regulated by emmprin.
癌胚蛋白（基底膜联蛋白，CD147）是一种属于免疫球蛋白超家族的细胞表面糖蛋白。它在肿瘤细胞表面高度表达，并刺激相邻的成纤维细胞或肿瘤细胞产生基质金属蛋白酶。此外，最近研究表明，癌胚蛋白还能刺激血管内皮生长因子和透明质酸的表达，分别导致血管生成和不依赖贴壁生长/多药耐药。这些发现使癌胚蛋白成为肿瘤进展中的一个重要分子，因此，作为抗肿瘤治疗的靶点更具吸引力。然而，在生理和病理条件下，癌胚蛋白的其他功能也正在被发现，包括作为T细胞的激活剂、单羧酸转运蛋白的伴侣、亲环素A的受体和神经识别分子。因此，开发控制癌胚蛋白特定功能的特异性方法至关重要，而阐明每种机制对于此至关重要。本综述将讨论癌胚蛋白在肿瘤进展中的作用以及癌胚蛋白调节的各种现象的分子机制的最新进展。
