Ikeda T, Yamamoto K, Takahashi K, Yamada M
Department of Neuropsychiatry, Yamaguchi University School of Medicine, Kogushi, Ube, Japan.
Acta Psychiatr Scand. 1991 Jun;83(6):444-8. doi: 10.1111/j.1600-0447.1991.tb05573.x.
We investigated the immune-associated antigens of peripheral lymphocytes from 13 patients with Alzheimer's disease (AD) and 13 age-matched healthy control subjects using two-color analysis with flow cytometry. Four ratios of immune-related antigens, T/B lymphocytes, CD4/CD8, CD4/CD45R and CD4/HLA-DR, were compared for the AD and control groups. The T/B and CD4/CD8 ratios did not differ between the groups, the ratio of CD4+CD45R+ subset in the AD group was lower than the ratio in the control group, and the ratios of CD4+ CD45R- and CD4+HLA-DR+ subsets in the AD group were significantly higher. Further, in the AD group, the CD4+ CD45R+/CD4+ ratio was lower and the CD4+ CD45R- CD4+ ratio was higher than in the control group.
我们使用流式细胞术双色分析，对13例阿尔茨海默病（AD）患者及13名年龄匹配的健康对照者外周淋巴细胞的免疫相关抗原进行了研究。比较了AD组和对照组免疫相关抗原的四个比率，即T/B淋巴细胞、CD4/CD8、CD4/CD45R和CD4/HLA-DR。两组间T/B和CD4/CD8比率无差异，AD组CD4+CD45R+亚群的比率低于对照组，而AD组CD4+CD45R-和CD4+HLA-DR+亚群的比率显著更高。此外，在AD组中，CD4+CD45R+/CD4+比率低于对照组，而CD4+CD45R-CD4+比率高于对照组。
