Wang Zhen-xia, Zhang Rui-ming, Yan Lü-nan, Wang Wen-tao, Jia Qian-bin
Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhonghua Gan Zang Bing Za Zhi. 2006 Jun;14(6):445-8.
To study the effectiveness of the lidocaine test in evaluating the liver reserve of rats with experimental liver injury in different phases.
40 healthy male Wistar rats were divided randomly into experimental and control groups. Rats of the experimental group received subcutaneous CCl4 in oil injection, and rats of the control group received saline injections. Monoethylglycinexylidide (MEGX) test, common hepatic function tests and histological examination of the livers were performed on all the rats.
With the development of the severity in liver injury, the concentrations of the serum MEGX in lidocaine test decreased gradually, which were consistent with liver histological changes. However, the results from the common liver function tests were all abnormal in the experimental group and were not consistent with the liver histological changes.
The results obtained from the MEGX test are more agreeable to liver histological changes than those from common liver function tests. The results from the MEGX test can represent liver histological changes concisely.
研究利多卡因试验在评估不同阶段实验性肝损伤大鼠肝脏储备功能中的有效性。
将40只健康雄性Wistar大鼠随机分为实验组和对照组。实验组大鼠接受皮下注射四氯化碳油剂，对照组大鼠接受生理盐水注射。对所有大鼠进行单乙基甘氨酰二甲苯胺（MEGX）试验、常规肝功能检查及肝脏组织学检查。
随着肝损伤严重程度的加重，利多卡因试验中血清MEGX浓度逐渐降低，与肝脏组织学变化一致。然而，实验组常规肝功能检查结果均异常，与肝脏组织学变化不一致。
MEGX试验结果比常规肝功能检查结果更符合肝脏组织学变化。MEGX试验结果能简洁地反映肝脏组织学变化。
