Suppr超能文献

重复经颅磁刺激改善帕金森病患者的情绪和运动功能

Repetitive transcranial magnetic stimulation to improve mood and motor function in Parkinson's disease.

作者信息

Helmich Rick C, Siebner Hartwig R, Bakker Maaike, Münchau Alexander, Bloem Bastiaan R

机构信息

Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

出版信息

J Neurol Sci. 2006 Oct 25;248(1-2):84-96. doi: 10.1016/j.jns.2006.05.009. Epub 2006 Jun 21.

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that can produce lasting changes in excitability and activity in cortical regions underneath the stimulation coil (local effect), but also within functionally connected cortical or subcortical regions (remote effects). Since the clinical presentation of Parkinson's disease (PD) is related to abnormal neuronal activity within the basal ganglia and cortical regions, including the primary motor cortex, the premotor cortex and the prefrontal cortex, several studies have used rTMS to improve brain function in PD. Here, we review the studies that have investigated the possible therapeutic effects of rTMS on mood and motor function in PD patients. We highlight some methodological inconsistencies and problems, including the difficulty to define the most effective protocol for rTMS or to establish an appropriate placebo condition. We finally propose future directions of research that may help to improve the therapeutic efficacy of rTMS in PD.

摘要

重复经颅磁刺激(rTMS)是一种非侵入性脑刺激技术,它可以在刺激线圈下方的皮质区域(局部效应)以及功能连接的皮质或皮质下区域(远程效应)产生兴奋性和活动的持久变化。由于帕金森病(PD)的临床表现与基底神经节和皮质区域(包括初级运动皮质、运动前皮质和前额叶皮质)内的异常神经元活动有关,多项研究已使用rTMS来改善PD患者的脑功能。在这里,我们回顾了研究rTMS对PD患者情绪和运动功能可能的治疗作用的研究。我们强调了一些方法上的不一致和问题,包括难以确定rTMS最有效的方案或建立合适的安慰剂条件。我们最后提出了未来的研究方向,这可能有助于提高rTMS在PD中的治疗效果。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验