Wang Yong-feng, Jin An-min, Wei Kun, Wang Xu-dong, Tang Shan-hua, Min Shao-xiong
Department of Othopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jun;26(6):754-6.
To develop an anti-infection nano-hydroxypatite (nano-HA) microsphere for local drug delivery for treating osteomyelitis.
The nano-HA was used as the core carrier to load gentamicin (GM) and coated with poly(-hydroxybutyrate-co- hydroxyvalerate)/polyethylene glycol (PHBV/PEG), which was degradable and biocompatible, to prepare nano-HA-PHBV/PEG-GM microsphere. The surface structure and in vitro drug-release of the microsphere were studied.
The microsphere had good drug delivery capability. The samples weighing 90 mg each were soaked in PBS and gentamicin release within the first day was 165.2 microg/ml, which maintained a low release rate in the following days. After 28 days, gentamicin release declined to 8.5 microg/ml, which was higher than the minimal inhibitory concentration of gentamicin (2 microg/ml).
The local drug delivery system has good drug-release performance in vitro and may possess potential value in clinical management of osteomyelitis.
开发一种用于局部给药治疗骨髓炎的抗感染纳米羟基磷灰石（nano-HA）微球。
以纳米羟基磷灰石为核心载体负载庆大霉素（GM），并用可降解且具有生物相容性的聚（-羟基丁酸酯-共-羟基戊酸酯）/聚乙二醇（PHBV/PEG）进行包衣，制备纳米羟基磷灰石-PHBV/PEG-GM微球。研究了微球的表面结构和体外药物释放情况。
微球具有良好的给药能力。将每份90毫克的样品浸泡在磷酸盐缓冲盐水中，第一天庆大霉素释放量为165.2微克/毫升，在接下来的几天里保持较低的释放速率。28天后，庆大霉素释放量降至8.5微克/毫升，高于庆大霉素的最低抑菌浓度（2微克/毫升）。
该局部给药系统在体外具有良好的药物释放性能，在骨髓炎的临床治疗中可能具有潜在价值。
