Hu Zhi-ming, Wang Hai-bin, Zhou Ming-qian, Yao Xin-sheng, Ma Li, Wang Xiao-ning
Institute of Molecular Immunology, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jun;26(6):785-7.
To observe the pathological changes in the blood vessels in rabbit femoral head with glucocorticoid-induced necrosis and investigate the pathogenesis of glucocorticoid-induced osteonecrosis.
Twenty New Zealand white rabbits were randomly divided into two groups, namely group A. which was injected with horse serum and prednisone and group B as the control group. Chinese ink was injected into the femoral cavity of the rabbits to observe the blood vessels in the femoral head under optical microscope and the femoral head was examined histopathologically.
Compared with the normal control group, the rabbits in group A had significantly decreased number of perfused vessels, which was featured by defective perfusion, osteocytie pyknosis or necrosis, increase of empty ostoocyte lacunae and fat cells, decrease of hematopoietic tissue, and blood vessel occlusion.
Vascular occlusion and vasculitis due to glucocorticoid treatment may cause avascular necrosis of the femoral head.
观察糖皮质激素诱导的兔股骨头坏死血管的病理变化，探讨糖皮质激素性骨坏死的发病机制。
将20只新西兰白兔随机分为两组，即A组，注射马血清和泼尼松；B组为对照组。向兔股腔内注入中国墨汁，在光学显微镜下观察股骨头血管，并进行股骨头组织病理学检查。
与正常对照组相比，A组兔灌注血管数量明显减少，表现为灌注不良、骨细胞固缩或坏死、空骨陷窝和脂肪细胞增多、造血组织减少以及血管闭塞。
糖皮质激素治疗导致的血管闭塞和血管炎可能引起股骨头缺血性坏死。
