Science to practice: Will improved assessment of response to antiangiogenic therapies be achieved with contrast-enhanced gray-scale US?

McCarville et al have used gray-scale contrast-enhanced low-mechanical-index, and thus non-bubble-destructive, continuous US to quantitate tumor blood flow in mouse tumors engineered to simulate antiangiogenic therapy. They have shown that contrast-enhanced gray-scale US, unlike power or color Doppler US performed without contrast enhancement, is better able to depict and distinguish microvascular flow in subcutaneously implanted mouse tumors possessing different vascular phenotypes.