Bierie Brian, Moses Harold L
Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Nat Rev Cancer. 2006 Jul;6(7):506-20. doi: 10.1038/nrc1926.
Transforming growth factor-beta (TGFbeta) signalling regulates cancer through mechanisms that function either within the tumour cell itself or through host-tumour cell interactions. Studies of tumour-cell-autonomous TGFbeta effects show clearly that TGFbeta signalling has a mechanistic role in tumour suppression and tumour promotion. In addition, factors in the tumour microenvironment, such as fibroblasts, immune cells and the extracellular matrix, influence the ability of TGFbeta to promote or suppress carcinoma progression and metastasis. The complex nature of TGFbeta signalling and crosstalk in the tumour microenvironment presents a unique challenge, and an opportunity to develop therapeutic intervention strategies for targeting cancer.
转化生长因子-β（TGFβ）信号通路通过在肿瘤细胞自身内部起作用或通过宿主-肿瘤细胞相互作用的机制来调节癌症。对肿瘤细胞自主TGFβ效应的研究清楚地表明，TGFβ信号通路在肿瘤抑制和肿瘤促进中具有机制性作用。此外，肿瘤微环境中的因素，如成纤维细胞、免疫细胞和细胞外基质，会影响TGFβ促进或抑制癌进展和转移的能力。TGFβ信号通路及其在肿瘤微环境中的串扰的复杂性带来了独特的挑战，也为开发针对癌症的治疗干预策略提供了契机。
