Romano Maria Fiammetta
Department of Biochemistry and Medical Biotechnologies, Federico II University, via Pansini 5, 80131 Naples, Italy.
Curr Opin Drug Discov Devel. 2009 Mar;12(2):253-63.
TGFbeta is a pleiotropic cytokine that has regulatory roles during embryonic development and adult tissue homeostasis, and is especially important for epithelial, neural and immune system differentiation and function. An increasing number of literature reports support a role for autocrine and paracrine TGFbeta-mediated processes in cancer. Progress in delineating the effects of TGFbeta in different tumors and stages of cancer has stimulated the development of TGFbeta-targeted therapies. This review describes the causes of TGFbeta malfunction in cancer, the rationale for therapeutic targeting of TGFbeta in human neoplasia, and the molecular strategies to modulate the signal.
转化生长因子β（TGFβ）是一种多效性细胞因子，在胚胎发育和成人组织稳态过程中发挥调节作用，对上皮、神经和免疫系统的分化及功能尤为重要。越来越多的文献报道支持自分泌和旁分泌TGFβ介导的过程在癌症中发挥作用。在阐明TGFβ在不同肿瘤及癌症阶段的作用方面取得的进展，推动了TGFβ靶向治疗的发展。本综述描述了癌症中TGFβ功能失调的原因、在人类肿瘤中靶向治疗TGFβ的理论依据以及调节该信号的分子策略。
