Tsuji M
HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, New York, New York 10016, USA.
Cell Mol Life Sci. 2006 Aug;63(16):1889-98. doi: 10.1007/s00018-006-6073-z.
Natural killer T (NKT) cells have been shown by a number of studies to play a protective role against cancers, autoimmune diseases and infectious diseases. Several glycolipids and phospholipids derived from mammalian, bacterial, protozoan and plant species have recently been identified as natural ligands (antigens) for NKT cells. Some of these glycolipid/phospholipid ligands have now been crystallized in forms bound to CD1d molecules, and the tertiary structure of these complexes has finally been revealed. This review is intended to list natural NKT cell ligands identified to date, and discuss how their structures relate to their propensity to bind CD1d molecules and, as a consequence, stimulate NKT cells.
多项研究表明，自然杀伤T（NKT）细胞在抵御癌症、自身免疫性疾病和传染病方面发挥着保护作用。最近，已鉴定出多种源自哺乳动物、细菌、原生动物和植物物种的糖脂和磷脂是NKT细胞的天然配体（抗原）。其中一些糖脂/磷脂配体现已以与CD1d分子结合的形式结晶，这些复合物的三级结构最终得以揭示。本综述旨在列出迄今为止已鉴定出的天然NKT细胞配体，并讨论它们的结构如何与其结合CD1d分子的倾向相关，进而刺激NKT细胞。
